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Inflammation and Human Health
Science programme: Human health and performance
This research aims to understand the health benefits of fruit and its extracts with particular emphasis on anti-stress, anti-oxidant, and immune modulatory pathways. The programme combines innovative in vitro, in vivo, and biosensor technologies to measure molecular and biochemical changes and the impact of fruit and fruit extracts. This knowledge will be utilised for fruit breeding programmes and for the development of functional health and wellness foods based on robust scientific health claims. Key targets are lung and muscle health in disease.
For a better understanding of our research, we recommend the following documents:
Hurst , S.M., McLoughlin, R.M., Monslow, J., Owens, S., Morgan, L., Fuller, G.M., Topley, N., & Jones , S.A. (2002). Secretion of Oncostatin M by infiltrating neutrophils: Regulation of IL-6 and chemokine expression in human mesothelial cells . J. Immunol., 169:5244-5251.
Hurst , S.M., Wilkinson, T.S., McLoughlin, R.M., Jones, S., Horiuchi, S., Yamamoto, N., Rose-John, S., Fuller, G.M., Topley, N., & Jones , S.A. (2001). IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation . Immunity, Volume 14, Issue 6, June 2001, Pages 705-714.
Tan, Kian H.; Purcell, Wendy M.; Heales, Simon J. R. 1; McLeod, Julie D.; Hurst, Roger D. CA
Activated T cells mediate direct blood-brain barrier endothelial cell death and dysfunction.
Neuroreport. 13(18):2587-2591, December 20, 2002.
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